Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.
ABSTRACT
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
PMID:33634602 | PMC:PMC7984223 | DOI:10.1002/alz.12202
Authors
Sandra Baez, PhD, MS
Neuroscientist, Neuropsychologist
Hernando Santamaría-García, MD, MSc, PhD
Psychiatrist and Researcher
Bárbara Costa Beber, PhD
Speech & Language Pathologist
Myriam De la Cruz Puebla, MD, MSc, PhD
Neurologist & Scientist
Laís Fajersztajn, PhD
Environmental Health Researcher
Adolfo M. García, PhD
Neuroscientist
Sara Silvia Kochen, MD, PhD
Neurologist, Clinical Researcher
Serggio Lanata, MD, MS
Associate Professor of Neurology
Bruce Miller, MD
Founding Director, University of California, San Francisco
Jorge Llibre Guerra, MD, MS
Behavioral Neurologist
Ioannis Tarnanas, PhD, MSc
Neuroscientist
Jennifer Yokoyama, PhD
Associate Professor of Neurology
Kate Possin, PhD
Professor of Neurology
Sebastian Moguilner, PhD
Neuroscientist
Jerónimo Martin, MD
Emergency Medicine Specialist
Lingani Mbakile Mahlanza, DPsyc
Clinical Neuropsychologist
Maira Okada de Oliveira, PhD
Neuropsychologist
Maritza Pintado-Caipa, MD
Neurologist
Stefanie Piña Escudero, MD
Geriatrician
Andrea Slachevsky, MD, PhD
Lea Tenenholz Grinberg, MD, PhD
Professor of Neurology and Pathology
Dominic Trépel, PhD
Assistant Professor of Health Economics
Agustín Ibáñez, PhD
Neuroscientist
