Overview
The preclinical stage of Alzheimer’s disease—in which the manifestation of the disease begins up to 20 years before any symptom becomes apparent—can be detected by biomarkers. However, even in this relatively “silent” stage, many individuals experience a subtle decline in cognition. The goal of this project is to study the relation between remote cognitive measures and in-person paper-and-pencil cognitive testing, and its performance as a function of core AD biomarkers.
Project Details
In this project, 200 cognitively unimpaired participants (aged 60-80 years) from the longitudinal B-AARC study of BarcelonaBeta Brain Research Center will receive an at-home computerized cognitive assessment. From different scores, a cognitive composite, called FLAME, will be computed to assess their relationship with a composite from in-person cognitive tests. Lastly, the association between the FLAME and core AD biomarkers will be explored. This project will provide empirical evidence of the efficacy of a remote computerized cognitive composite for identifying cognitively unimpaired individuals at risk of AD. Furthermore, the results will allow us to take a step forward to promote equity in accessing cognitive assessments and reduce disparities in dementia prevention.
Members involved
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