Volume of β-Bursts, But Not Their Rate, Predicts Successful Response Inhibition

J Neurosci. 2021 Jun 9;41(23):5069-5079. doi: 10.1523/JNEUROSCI.2231-20.2021. Epub 2021 Apr 29.

ABSTRACT

In humans, impaired response inhibition is characteristic of a wide range of psychiatric diseases and of normal aging. It is hypothesized that the right inferior frontal cortex (rIFC) plays a key role by inhibiting the motor cortex via the basal ganglia. The electroencephalography (EEG)-derived β-rhythm (15-29 Hz) is thought to reflect communication within this network, with increased right frontal β-power often observed before successful response inhibition. Recent literature suggests that averaging spectral power obscures the transient, burst-like nature of β-activity. There is evidence that the rate of β-bursts following a Stop signal is higher when a motor response is successfully inhibited. However, other characteristics of β-burst events, and their topographical properties, have not yet been examined. Here, we used a large human (male and female) EEG Stop Signal task (SST) dataset (n = 218) to examine averaged normalized β-power, β-burst rate, and β-burst "volume" (which we defined as burst duration × frequency span × amplitude). We first sought to optimize the β-burst detection method. In order to find predictors across the whole scalp, and with high temporal precision, we then used machine learning to (1) classify successful versus failed stopping and to (2) predict individual stop signal reaction time (SSRT). β-burst volume was significantly more predictive of successful and fast stopping than β-burst rate and normalized β-power. The classification model generalized to an external dataset (n = 201). We suggest β-burst volume is a sensitive and reliable measure for investigation of human response inhibition.SIGNIFICANCE STATEMENT The electroencephalography (EEG)-derived β-rhythm (15-29 Hz) is associated with the ability to inhibit ongoing actions. In this study, we sought to identify the specific characteristics of β-activity that contribute to successful and fast inhibition. In order to search for the most relevant features of β-activity, across the whole scalp and with high temporal precision, we employed machine learning on two large datasets. Spatial and temporal features of β-burst "volume" (duration × frequency span × amplitude) predicted response inhibition outcomes in our data significantly better than β-burst rate and normalized β-power. These findings suggest that multidimensional measures of β-bursts, such as burst volume, can add to our understanding of human response inhibition.

PMID:33926997 | PMC:PMC8197646 | DOI:10.1523/JNEUROSCI.2231-20.2021